downregulation of il-12 production in healthy non-responder neonates to recombinant hepatitis b vaccine
Authors
abstract
a proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis b (hb) vaccine. unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. in this study, il-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group of responder and non-responder neonates. our results indicate significantly decreased production of hbsag-induced il-12 in non-responder subjects compared to responders (p<0.01). since il-12 is produced mainly by antigen presenting cells (apc) and is considered to be crucial for initiation and polarization of cd4+ t-cell function, therefore, our findings could be interpreted to imply apc dysfunction in non-responder vaccinees
similar resources
Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine
A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...
full textUnresponsiveness to Recombinant Hepatitis B Vaccine in Healthy Iranian Neonates: Association with HLA Antigens
Background: Hepatitis B is an important infectious disease. Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran. However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination.Objectives: To investigate distribution of HLA class-I and class-II antigens in health...
full textDistribution of Circulating Immune Cells in Responder and Non-Responder Individuals to Hepatitis B Vaccine
Unresponsiveness to hepatitis B surface antigen (HBsAg) has been shown to be associated with dysfunction of the presenting cells (APC) and defect in the specific B-lymphocyte and/or T-lymphocyte repertoires. Direct determination of the frequency of specific T-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...
full textdistribution of circulating immune cells in responder and non-responder individuals to hepatitis b vaccine
unresponsiveness to hepatitis b surface antigen (hbsag) has been shown to be associated with dysfunction of the presenting cells (apc) and defect in the specific b-lymphocyte and/or t-lymphocyte repertoires. direct determination of the frequency of specific t-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...
full textUnresponsiveness to Recombinant Hepatitis B Vaccine in Healthy Iranian Neonates: Association with HLA Antigens
Background: Hepatitis B is an important infectious disease. Since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of Iran. However, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. Objectives: To investigate distribution of HLA class-I and class-II antigens in healthy...
full textunresponsiveness to recombinant hepatitis b vaccine in healthy iranian neonates: association with hla antigens
background: hepatitis b is an important infectious disease. since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of iran. however, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. objectives: to investigate distribution of hla class-i and class-ii antigens in healt...
full textMy Resources
Save resource for easier access later
Journal title:
iranian biomedical journalجلد ۸، شماره ۱، صفحات ۴۱-۴۵
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023